Serpins in Prokaryotes

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Serpins in prokaryotes.

Members of the serpin (serine proteinase inhibitor) superfamily have been identified in higher multicellular eukaryotes (plants and animals) and viruses but not in bacteria, archaea, or fungi. Thus, the ancestral serpin and the origin of the serpin inhibitory mechanism remain obscure. In this study we characterize 12 serpin-like sequences in the genomes of prokaryotic organisms, extending this ...

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Fig. 1. Representative crystal structures of members of the serpin family. Cartoon diagrams were produced using MOLSCRIPT (21): A. bovine trypsin proteinase inhibitor, pdb accession 1BPI B. cleaved antitrypsin, 7API C. inact ovalbumin, 1OVA D. inact antitrypsin, 1QLP E. docking complex between inactive trypsin and serpin 1K, 1I99 F. covalent complex between trypsin and antitrypsin, 1EZX G. late...

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Transcriptional activation or 'rewiring' of silent genes is an important, yet poorly understood, phenomenon in prokaryotic genomes. Anecdotal evidence coming from experimental evolution studies in bacterial systems has shown the promptness of adaptation upon appropriate selective pressure. In many cases, a partial or complete promoter is mobilized to silent genes from elsewhere in the genome. W...

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ژورنال

عنوان ژورنال: Molecular Biology and Evolution

سال: 2002

ISSN: 0737-4038,1537-1719

DOI: 10.1093/oxfordjournals.molbev.a004012